Abstract
Background: Nonunion accounts for 2 to 10% of fracture complications. It diminishes the quality of life and increases the risk of mortality. Several circumstances, including smoking, metabolic disorders, dietary inadequacy, and nonsteroidal anti-inflammatory drugs (NSAIDs), may predict the development of nonunion. In order to treat postoperative pain, NSAIDs are frequently used, including orthopedic conditions, particularly in the pain management of fracture. Using NSAIDs/cyclooxygenase (COX)-2 inhibitors has been controversial for many years. Many orthopedic surgeons avoid using them in fracture surgery due to the potential harmful effect on osteogenesis and subsequent nonunion risk. Literature Review: We conducted an updated review of the literature using digital databases such as PubMed, Cochrane, Ovid-SP, Springer Link, and Science Direct, including “NSAIDs” OR “COX-2 Inhibitor” AND “nonunion” AND “fracture surgery”. In total 7 publications that met our inclusion criteria were summarized. This literature review revealed that some studies have proved that NSAIDs/COX-2 inhibitors are capable of inhibiting the fracture union temporarily; however, other studies have shown the safety of NSAIDs following fracture fixation without remarkable interference on bone healing. The association of COX-2 inhibitors or non-selective NSAIDs with nonunion remains unclear. Conclusion: Prolonged use of NSAIDs interferes with the response to a successful bone healing. Short-duration (< 2 weeks of treatment) and low-dose use of NSAIDs are considered safe and efficacious for fracture postoperative pain.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: (JOINTS) Journal Orthopaedi and Traumatology Surabaya
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.