Abstract

Anxiety and depression are commonly comorbid with painful diabetic peripheral neuropathy (DPN). Data from 3 randomized, placebo-controlled, 8-13 week trials of pregabalin (300 or 600 mg/d) as treatment of painful DPN were pooled and retrospectively analyzed to investigate relationships between changes in pain and severity of anxiety and depression. Endpoint–LOCF mean pain score (MPS, scale of 0 [no pain] to 10 [worst possible pain]) was the primary efficacy measure, and the Hospital Anxiety and Depression Scale anxiety (HADS-A) and depression (HADS-D) subscales were secondary efficacy measures.

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