Abstract
Morphological and morphometric data showing a higher number of mast cells (MCs) in the stroma of B-cell non-Hodgkin's lymphomas (B-NHL) than in benign lymphadenopathies are presented in support of the suggestion that angiogenesis during the progression of B-NHL may be partly mediated by angiogenic factors in their secretory granules.
Highlights
Many data suggest that the density of mast cells (MCs) is highly correlated with the extent of both normal and pathological angiogenesis, such as that in chronic inflammatory diseases and tumours
In experimentally induced tumours too, MCs accumulate close to the tumour cells before the onset of angiogenesis (Kessler et al, 1976), and in tumours induced in MC-deficient mice both the reduced angiogenesis and the ability to produce metastasis have been shown (Starkey et al, 1988; Dethlefsen et al, 1994)
Angiogenesis is fundamental for tumour progression in the form of growth, invasion and metastasis (Folkman, 1995)
Summary
Representative samples of 74 B-NHL nodes and 12 benign lymphadenopathies obtained with informed consent before therapy were studied (Table 1). B-NHLs were classified according to the Received 27 June 1997 Accepted 29 September 1997. Correspondence to: D Ribatti, Institute of Human Anatomy, Histology and Embryology, Piazza Giulio Cesare, 11, Policlinico, 1-70124 Bari, Italy. Lymphadenopathies were nine reactive and three atypical lymphoid hyperplasias. Reactive forms displayed either follicular hyperplasia (lymphadenitides, rheumatoid lymphadenopathies) or histiocyte hyperplasia (those draining carcinomas). Each sample was divided into two parts immediately after surgical removal: one part was formalin fixed and paraffin embedded for histopathology and immunohistochemistry; the second was processed for electron microscopy
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