DO INCREASED LEVELS OF TRIGLYCERIDES CONSIST AN INDEPENDENT RISK FACTOR DEFINING THE SEVERITY OF CARDIOMYOPATHY IN T2DM PATIENTS WITH KNOWN HYPERTENSION ?

Abstract

Objective: The association of diabetes mellitus and heart disease is well established in evidence-based medical practice in our days. Diabetes Mellitus is also associated with various cardiovascular risk factors including hypertension and hypertriglyceridemia. Therefore, the severity of Cardiomyopathy in Diabetics is interdependent among these various risk factors. The aim of this study was to assess that hypertriglyceridemia is an independent risk factor of the severity of cardiomyopathy in T2DM patients with known Hypertension. Design and method: 451 (249male, 202 female) T2DM Hypertensive patients participated on this study. Age range of the patients was between 48–79 years of age. All patients were assessed for cardiac functioning with Echocardiography and Ventriculographies. Severity of Cardiomyopathy was estimated measuring LVEDP with a borderline > 15 mm Hg. TGC were measured in serum blood analysis of patients in SI units. Data were analyzed using ANOVA and logistic regression analysis. Hypertriglyceridemia was analyzed as an independent risk factor. Data is presented as mean ± standard deviation and level of significance was accepted when p < 0.05. Results: Data were analyzed on 451(249 male, 202 female) hypertensive T2DM patients, 91 (20.2%) presented with TGC level of 2.9 ± 0.8 mmol/L, and a LVEDP of 16.2 ± 0.8 mm Hg. 109 patients (24.1 %) with TGC level of 3.6 ± 0.7 mmol/L, and a LVEDP of 17.8 ± 0.9 mm Hg. 132 (29.3%) TGC level of 4.1 ± 0.3 mmol/L, and a LVEDP of 19.4 ± 0.8 mm Hg and 119 (26.4%)patients with TGC level of 4.7 ± 0.6 mmol/L, and a LVEDP of 21.1 ± 0.8 mm Hg. Data Analysis revealed that hypertriglyceridemia p = 0.019 is an independent risk factor of cardiomyopathy in T2DM hypertensive patients and leads in markedly increased Left Ventricular End Diastolic Pressures p = 0.022. Conclusions: Hypertriglyceridemia is an independent risk factor of Cardiomyopathy in Hypertensive T2DM patients.