Do Gonadotropins Influence Serum Lipoprotein(a) Concentrations? Observations on Children, Adolescents and Adults

Abstract

Data from 7045 subjects were examined. The main groups consisted of the following in- and outpatients: 1414 neonates, 2554 children and adolescents (1336 males, 1218 females), 1209 women directly postpartum, 786 non-pregnant women and 1090 men aged between 18 and 100 years of age. Unless otherwise stated, persons were under medical observation or therapy. The results were obtained over a three-year period using an in-house immunoluminometric assay specific for apolipoprotein(a) using two polyclonal antibodies and single lot of reagents to allow for comparability of results. Girls aged between 10 and 12 years of age had significantly higher serum lipoprotein(a) (median 124 mg/l) levels than boys (median 88 mg/l) of the same age (p < 0.05-Mann-Whitney U-test). Post-pubertal lipoprotein(a) concentrations were not significantly different from pre-pubertal levels. Between the ages of 0-9 and 13-17 years there were no statistically significant sex-linked differences in serum lipoprotein(a). In adults, lipoprotein(a) serum levels were significantly higher in women (median 163 mg/l) aged between 50 and 59 years, when compared with men (median 128 mg/l) of the same age group (p = 0.05-Kruskal-Wallis one way ANOVA followed by the Nemenyi test). There was no significant difference in serum lipoprotein(a) concentrations between healthy women (median 91 mg/l), women direct postpartum (median 116 mg/l) and in-patient women (median 117 mg/l) aged between 18 and 41 years of age (p = 0.11-0.96). There was no correlation between maternal lipoprotein(a) and birth weight in mature newborns (r = -0.028-0.085). The results may indicate a direct influence of gonadotropins at puberty and during the menopause which cause an increase in serum lipoprotein(a) concentrations.