Abstract
To investigate the possible functional relationship between 5-HT 1 and 5-HT 2 receptors, we studied the effects of a nonselective 5-HT agonist (5-MeO DMT), a 5-HT 1A-selective (8-OH-DPAT) and a 5-HT 1B/5-HT 1C-selective (TFMPP) agonist on the head-twitch behavior induced by the putative 5-HT 2-selective receptor agonist (±)-DOI. In the mouse (±)-DOI produced the head-twitch response in a dose-dependent manner and (−)-DOI was twice as potent as the (+) isomer. Selective 5-HT 2 antagonists, ketanserin and spiperone, dose-dependently inhibited the (±)-DOI-induced head-twitch response. The nonselective and the 5-HT 1A-selective agonists also dose-dependently reduced the behavior, whereas 5-HT 1B/5-HT 1C-selective agonist (TFMPP) failed to affect the (±)-DOI-induced response. Taken together with previously published literature data, we propose a 5-HT 1A inhibitory action on the 5-HT 2 receptor-mediated response when induced by its selective agonist (±)-DOI.
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