Abstract
Drugs which alter the balance of neurotransmitter activity may, while failing to cause gross structural malformations of the brain, produce long-lasting functional disturbances if given when the brain is developing. Subtle anatomical changes may underlie such disturbances; reserpine has been shown to interfere with cell proliferation in the brain of suckling rats, and long-term alterations in behaviour reported after treatment with reserpine may be related to this effect of the drug. Neurotransmitters, apart from their conventional role, may also function as neurohumours and be involved in the regulation of cell proliferation in the nervous system. Thus drugs influencing central neurotransmitter activity, such as phenothiazines and adrenergic agonists and antagonists, which in clinical practice are often given to pregnant mothers, may affect the developing brain through mechanisms similar to those reported for reserpine. More experimental information is needed about the influence of such drugs on cell proliferation in the brain, and about their "behavioural teratogenicity".
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