Abstract
Using synchrotron small angle X-ray scattering and energy dispersive X-ray diffraction, we have found that cationic liposomes made of the monovalent cationic lipid, 3-[ N-( N, N-dimethylaminoethane)-carbamoyl]cholesterol (DC-Chol) and the neutral lipid dioleoylphosphatidylethanolamine (DOPE) condense DNA molecules forming complexes (DC-Chol/DOPE-DNA) which are not assembled in an inverted hexagonal structure as recently reported, but, conversely, form a well-ordered lamellar liquid-crystalline phase with distinct regimes of DNA packing density.
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