Abstract
To the Editor: We read with great interest the recent article by Heublein et al1 on plasma pro-BNP1-108 measurement with commercially available assay kits and the effect of pro-BNP1-108 on cGMP levels. They demonstrated that Shionogi’s or Biosite’s triage assay kit did not cross-react with pro-BNP1-108 and that pro-BNP1-108 did not increase intracellular cGMP levels in cardiac myocytes or fibroblasts. Shionogi’s immunoradiometric assay kit uses 2 monoclonal antibodies: one recognizes the ring portion and the other recognizes the C-terminal tail. Therefore, this assay kit measures B-type natriuretic peptide independent of the length of the N-terminal extension from the ring structure. Indeed, Heublein et al1 reported that this assay …
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
