Abstract
Objective:To determine whether medical history, clinical examination and human papilloma virus (HPV) genotype influence spontaneous regression in cervical intraepithelial neoplasia grade I (CIN-I).Material and Methods:We retrospectively evaluated 232 women who were histologically diagnosed as have CIN-I by means of Kaplan-Meier curves, the pattern of spontaneous regression according to the medical history, clinical examination, and HPV genotype.Results:Spontaneous regression occurred in most patients and was influenced by the presence of multiple HPV genotypes but not by the HPV genotype itself. In addition, regression frequency was diminished when more than 50% of the cervix surface was affected or when an abnormal cytology was present at the beginning of follow-up.Conclusion:The frequency of regression in CIN-I is high, making long-term follow-up and conservative management advisable. Data from clinical examination and HPV genotyping might help to anticipate which lesions will regress.
Highlights
Cervical cancer and its precancerous lesions represent a major health issue, which needs early intervention in order to prevent high morbidity and mortality rates
The natural history of human papilloma virus (HPV) infection indicates that following an initial HPV infection, a number of patients develop low-grade squamous intraepithelial lesions (LSIL), known as cervical intraepithelial neoplasia grade I (CIN-I) [4], which occasionally progresses to highgrade squamous intraepithelial lesion (HSIL) [5, 6] requiring exhaustive management and follow-up
The aim of this study was to determine whether clinical information and HPV genotyping were useful to predict the frequency of regression and the need of treatment in CIN-I [14,15,16]
Summary
Cervical cancer and its precancerous lesions represent a major health issue, which needs early intervention in order to prevent high morbidity and mortality rates. The majority of CIN-I lesions regress without medical intervention, making treatment at this stage superfluous and cost-ineffective [7]. Over-treatment at early stages should be avoided [8], especially in young women, and follow-up periods should be encouraged to make HPV clearance and histologic regression amenable [9]. The aim of this study was to determine whether clinical information (medical history and examination) and HPV genotyping were useful to predict the frequency of regression and the need of treatment in CIN-I [14,15,16]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Journal of the Turkish German Gynecological Association
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
