Abstract
Aim. To assess changes of cognitive function in population older 55 y. in relation with childhood life conditions.Material and methods. The study is a part of prospective cohort trial “Stress, ageing and health”. Totally, 1816 participants included, of those 20% (358) with declined cognitive ability. Childhood life conditions were evaluated with the questions: “Characterize the place where you spent most of your childhood”, “Education level of your parent”, “When you were growing up, was your family wealth better or worse than average that times?”, “When you were growing up, how often you went to bed with hunger due to lack of food in your family?”. Life quality was measured with the score Mini-Mental State Examination (MMSE), and decreased life quality was set if less than 24 points from 30. Associations were evaluated with logistic regression after correction for social and demographic parameters, alcohol intake status and diagnoses of arterial hypertension and stroke.Results. With analysis of decreased cognitive function association and conditions of life, it was found that childhood in rural areas increases the risk of the problem 1,6 times (p=0,001). Higher education of father (not mother) decreases the risk of lower cognitive functioning by 45% (p=0,001). There were significant associations of hunger in childhood with decreased cognitive function (p=0,006). Also, the lower wealth in the family where participant was growing up, the higher risk of decreased cognitive functioning at later stage of life (HR 1,68 (95% CI 1,07-1,94) p=0,02).Conclusion. Results of the current study witness on the presence of adverse childhood life circumstances and cognition decline at adulthood.
Highlights
With analysis of decreased cognitive function association and conditions of life, it was found that childhood in rural areas increases the risk of the problem 1,6 times (p=0,001)
В то же время, Lyu J, et al показали, что наличие в семье высокого достатка снижало риск возникновения данной патологии на 23%, а по данным других авторов, нехватка еды, независимо от возраста, приводила к когнитивным нарушениям [10, 13, 14]
The Long Arm of Childhood in China: Early-Life Conditions and Cognitive Function Among Middle-Aged and Older Adults
Summary
При анализе ассоциаций сниженной КФ функции с условиями жизни оказалось, что детство, проведенное в сельской местности, увеличивает риск данной патологии в 1,6 раз (р=0,001). Результаты настоящего исследования свидетельствуют о наличии связи неблагоприятных условий в детстве с наличием когнитивных нарушений в зрелом возрасте. Ключевые слова: сниженная когнитивная функция, условия жизни в детстве, место проживания, социально-экономический статус. Отдела эпидемиологии хронических неинфекционных заболеваний, Капустина А. Отдела эпидемиологии хронических неинфекционных заболеваний, Баланова Ю. Лаборатории экономического анализа эпидемиологических исследований и профилактических технологий отдела эпидемиологии хронических неинфекционных заболеваний, Муромцева Г. М.н., профессор, руководитель отдела эпидемиологии хронических неинфекционных заболеваний, Школьников В. АГ — артериальная гипертония, САД — систолическое артериальное давления, ДАД — диастолическое артериальное давление, ДИ — доверительный интервал, КФ — когнитивная функция, ОР — относительный риск, MMSE — Mini-Mental State Examination. Рукопись получена 05.03.2018 Рецензия получена 07.03.2018 Принята к публикации 14.03.2018
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