Abstract
BackgroundSpectral domain optical coherence tomography (SD-OCT) is a widely applied non-invasive technique for evaluating optic nerve head parameters. The aim of this study was to evaluate the impact of biometric parameters such as the spherical equivalent (SE) and the anterior corneal curvature (ACC) on the peripapillary retinal nerve fiber layer (pRNFL), Bruch’s membrane opening (BMO), and the minimum rim width (MRW) measurements performed by spectral domain optical coherence tomography (SD-OCT) in glaucomatous and healthy eyes.MethodsIn this cross-sectional, case–control prospective pilot study, the glaucoma group consisted of 50 patients with previously diagnosed and treated glaucoma and one healthy group of 50 subjects. Two consecutive examinations of pRNFL, BMO, and MRW with SD-OCT for every patient were performed without ACC and objective refraction (imaging 1) and with them (imaging 2).ResultsThe interclass correlation coefficient (ICC) reflected high agreement between imaging 1 and imaging 2 in both groups. The ICC in the glaucoma and healthy groups for pRNFL (0.99 vs. 0.98), BMO (0.95 vs. 0.97), and MRW (1.0 vs. 1.0) was comparable.ConclusionsOur preliminary data from a small number of eyes showed that the measurements of pRNFL, MRW, and BMO reflected high agreement between both imaging techniques with ACC and objective refraction and without these parameters in subjects with a refractive error up to ± 6.0 diopters. Further studies with participants with higher refractive error are necessary to evaluate the impact of biometric parameters such as SE and ACC on measurements with SD-OCT.
Highlights
Spectral domain optical coherence tomography (SD-OCT) is a widely applied non-invasive technique for evaluating optic nerve head parameters
Due to the increasing interest in the topic and the lack of publications in this field, the aim of this study was to evaluate the impact of biometric parameters such as spherical equivalent (SE) and anterior corneal curvature (ACC) on the peripapillary retinal nerve fiber layer (pRNFL), Bruch’s membrane opening (BMO), and minimum rim width (MRW) measurements performed by SD-OCT in glaucomatous and healthy eyes
We evaluated two consecutive examinations of pRNFL, BMO, and MRW with SD-OCT for every eye, carried out for quality assurance (Table 1)
Summary
Spectral domain optical coherence tomography (SD-OCT) is a widely applied non-invasive technique for evaluating optic nerve head parameters. The aim of this study was to evaluate the impact of biometric parameters such as the spherical equivalent (SE) and the anterior corneal curvature (ACC) on the peripapillary retinal nerve fiber layer (pRNFL), Bruch’s membrane opening (BMO), and the minimum rim width (MRW) measurements performed by spectral domain optical coherence tomography (SD-OCT) in glaucomatous and healthy eyes. Spectral domain optical coherence tomography (SDOCT) is a widely applied non-invasive technique for evaluating optic nerve head (ONH) parameters such as the peripapillary retinal nerve fiber layer (pRNFL), Bruch’s. A super luminescence diode with an infrared beam central wavelength of 870 nm, which can acquire B-scans with a thickness of 11 μm It provides a normative database of pRNFL thicknesses from healthy Caucasian subjects, leading to the possibility of performing quantitative analysis and comparing the results. Damage of ONH is the first sign of glaucomatous optic neuropathy and is only later followed by associated visual field defect, demonstrating the importance of a structural examination of ONH, especially during the early stages of the disease [12]
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