DNAzyme-assisted bioconstruction of logically activatable nanoplatforms for enhanced cancer therapy

Abstract

Multifunctional therapeutic nanoplatforms with an activatable property have demonstrated the ability to enhance cancer therapy due to their intrinsiccontrollability in drug delivery. Although much effort has been focused on constructing multifunctional therapeutic nanoplatforms with an activatable property, developing logically activatable nanoplatforms to exert improved therapeutic efficiency against cancer remains an imperative need. In this study, we established a tumor microenvironment activable nanoplatform by the DNAzyme assisted coating of polyaniline (PANI) on the surface of mesoporous silica nanoparticles (MSNs). This mild synthetic strategy can avoid the destruction of the loaded biomolecules and guaranteethe biosafety of the nanoplatforms. Furthermore, the activable polymer can be used to load siRNA for combinedcancer treatment. When the composite nanoplatforms were enriched in the tumor, the acidic tumor microenvironment activated the nanocarrier and unloaded the drugs and siRNA upon near-infrared (NIR) irradiation to achieve controlled drug delivery for enhanced cancer therapy.