Abstract
DNA nanotechnology, based on sequence-specific DNA recognition, could allow programmed self-assembly of sophisticated nanostructures with molecular precision. Extension of this technique to the preparation of broader types of nanomaterials would significantly improve nanofabrication technique to lower nanometer scale and even achieve single molecule operation. Using such exquisite DNA nanostructures as templates, chemical synthesis of polymer and inorganic nanomaterials could also be programmed with unprecedented accuracy and flexibility. This review summarizes recent advances in the synthesis and assembly of polymer and inorganic nanomaterials using DNA nanostructures as templates, and discusses the current challenges and future outlook of DNA templated nanotechnology.
Highlights
In 1953, the double helix structure of DNA was discovered, which revealed the mystery of life and enabled people to understand clearly the composition and transmission of genetic information [1]
Seidel and colleagues used the DNA origami cavity as a mold to control the growth of gold nanoparticles, and this process was successfully observed by TEM spectroscopy with stepwise addition of chloroauric acid [98, 99]
This review summarizes recent progress in nanomaterials synthesis based on DNA nanostructure templates
Summary
DNA, often known as the genetic code, exists in natural organisms. In 1953, the double helix structure of DNA was discovered, which revealed the mystery of life and enabled people to understand clearly the composition and transmission of genetic information [1]. Two reversely parallel complementary DNA single strands can recognize each other via Watson–Crick base pairing, forming a stable DNA. This article is part of the Topical Collection “DNA Nanotechnology: From Structure to Functionality”; edited by Chunhai Fan, Yonggang Ke
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