Abstract
In recent years, increasing attention has been paid to DNA mediated chemiluminescence (CL) bioassays due to the merits provided by both of CL and functional DNAs. CL exhibits the advantages of low background, high sensitivity and simple equipment. Meanwhile, various functional DNAs facilitate the target recognition, signal transduction and signal amplification of the CL bioassays. However, a comprehensive summarization focused on the DNA-mediated CL bioassays is still lacking now. In this review, the CL systems for biosensing and approaches of DNA-based target recognition and signal transduction for CL bioassays were summarized. The strategies and mechanisms of signal amplification and background reducing for ultrasensitive CL assays were also discussed in detail. The applications for the detection of various analytes including nucleic acids, proteins, toxins, environmental pollutants, and metal ions were systematically reviewed as well. Finally, the further prospects and challenges were highlighted to promote the advancement of DNA-mediated CL bioassays.
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