Abstract
This article discusses the DNA-interacting molecules and cancer treatments. A crucial step in reproduction is the passage of genetic information from the parent cell to the daughter cell. DNA replication starts with a double-stranded DNA molecule and produces its two identical copies. The process of transcription commences by binding of an enzyme RNA polymerase (RNA Pol) to the template DNA strand. Noncovalent drug binding can be classified into two categories: DNA groove binders and intercalators. Numerous enzymes are involved in this important cellular event, namely, DNA polymerases, helicases, topoisomerases, primase, telomerase, recombination/repair enzymes, DNA ligase, endonucleases, exonucleases, and DNA-modifying enzymes (acetylases and methylases). The growth of cancer may be initiated by environmental agents (physical, chemical, radiation, and viruses) and inherited genetic mutations. Cancer immunotherapy exploits this property of immune system to treat cancer. Cancer immunotherapy is categorized into three main categories, that is, cell-base therapy, cytokine therapy, and antibody-based therapy. Keywords: cancer immunotherapy; cancer treatments; DNA-interacting molecules; DNA polymerases; DNA replication; helicases; noncovalent drug binding; topoisomerases
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