Abstract
A tetra substituted neutral zinc phthalocyanine (ZnPc-4) bearing 4-phenylazophenoxy group at the periphery had been prepared from zinc acetate dihydrate Zn(CH3COO)2·2H2O and 4-(phenylazophenoxy)phthalonitrile. The interaction of neutral metallophthalocyanine, ZnPc-4 with Calf Thymus (CT) DNA was investigated using absorption titrations, competitive Fluorescent Intercalator Displacement (FID) assay, minor groove binding assay and viscosity measurement. The binding studies revealed a probable intercalative mode of interaction of ZnPc-4 with DNA with an appreciable binding constant. The bovine serum albumin (BSA) binding activity of ZnPc-4 was evaluated by fluorescence titration.
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