Abstract
The DNA-binding mode of 9-Phenyl carbazole with CT-DNA was investigated by absorption spectroscopy, EB-DNA displacement, circular dichroism, thermal denaturation and viscosity measurements. Results indicated that these compounds intercalate into the base pairs of CT-DNA. The effect of ionic strength on the fluorescence property of the system indicated the presence of electrostatic interaction via phosphate backbone of DNA helix. The intrinsic binding constant values suggested that compound has DNA binding propensity. This compound promote the cleavage of plasmid pBR322. These results may be useful for the design of 9-Phenyl carbazole with desired binding characteristics and useful to better understand the DNA binding mode of heterocyclic compound.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Advanced Research in Science, Communication and Technology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
