Abstract
We have compared in mice the overall toxicity of free adriamycin (ADR) or DNA bound adriamycin (ADR-DNA) after repeated i.v. injections of high drug doses ( 35–40 mg/kg). Survival curves and variations in mean total body weight indicated that ADR-DNA is less toxic than ADR in mice. Histopathologic studies showed: (1) that ADR induced severe lesions in the hemopoietic organs (bone marrow, lymph nodes, spleen, thymus) and in the gastrointestinal tract. An important lipid overloading in liver and kidney was observed; (2) that the toxicity of ADR is reduced for bone marrow and stomach when the drug is associated with high mol. wt DNA. No lipid overloading has been seen in liver and kidney of the complex treated mice. The repair of the lesions induced in the tissues (lymphoid organs, thymus) which are not protected against the effect of ADR when using a DNA-complex, is significantly more rapid. Finally, in this subacute study in mice, no cardiomyopathy has been observed after treatment with either free or DNA bound drug.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
