Abstract
Background Immunodominance and sequence diversity are major hurdles in the development of effective HIV vaccines. We tested the hypothesis that a vaccine candidate composed of strictly Conserved Elements (CE) of the HIV proteome excluding the variable regions would help overcome problems of viral sequence diversity and potential negative effects of immunodominance. Seven CE were identified in p24. Vaccination of macaques with p55DNA failed to elicit cellular or humoral immune responses to the CE, while epitopes outside of the CE were immunogenic.
Highlights
Immunodominance and sequence diversity are major hurdles in the development of effective HIV vaccines
We tested the hypothesis that a vaccine candidate composed of strictly Conserved Elements (CE) of the HIV proteome excluding the variable regions would help overcome problems of viral sequence diversity and potential negative effects of immunodominance
CEvac DNA prime-p55gagDNA boost in mice led to similar conclusions
Summary
Immunodominance and sequence diversity are major hurdles in the development of effective HIV vaccines. DNA vaccines expressing conserved elements provide potent and broad immune responses From AIDS Vaccine 2012 Boston, MA, USA. Background Immunodominance and sequence diversity are major hurdles in the development of effective HIV vaccines.
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