Abstract
Publisher Summary The chapter discusses the role of deoxyribonucleic acid (DNA) structure in gene regulation. It also considers the properties and conformations of various DNAs and review static structure as well as dynamic transitions. Some of the goals of current research in this area are the following: (1) determination of the properties of regions of DNA along the high molecular-weight chromosomes; (2) identification of the interactions between the neighboring regions of DNA; (3) determination of how the properties of DNA influence the specificity or affinity of regulatory proteins that interact with specific regions of DNA; (4) identification of how the interaction of regulatory proteins, with DNA, modifies the properties of the DNA target site; (5) investigation of the presumed correlation between the physical properties of a region of DNA and its genetic function. A complete knowledge of the kinetic and equilibrium properties of the interaction of specific DNA target sites, with important regulatory proteins, is fundamental for the eventual comprehension of gene regulation. Cellular differentiation is the orderly and programmed expression of a family of genes. Alternatively, the malignant transformation of a cell will eventually be recognized as a faulty interaction between one or more key proteins and their DNA receptor sites.
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