Abstract
Through this research, functionalized graphene nanopores are used to verify how effective such an apparatus for DNA sequencing is. The circular symmetric pores are functionalized with hydrogen and a hydroxyl group bonded with carbon atoms of the pore rim. Plus, two adenine bases are also put at the rim perimeter to verify whether such a combination would lead to base detection. A homopolymer of single-stranded DNA (ssDNA) is pulled through a nanopore using steered molecular dynamics (SMD) simulation. Pulling force profile, moving fashion of ssDNA in irreversible DNA pulling as well as the base orientation during translocation relative to the graphene plane, called beta angle, are assessed. Based on the studied parameters, SMD force, and base orientation, the hydrogenated and hydroxylated pores do not show a clear distinction between bases, while the adenine-functionalized pore can distinguish between adenine and cytosine. Therefore, there may be some hope for achieving single-base sequencing, while further research is needed.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
