DNA Repair Gene Polymorphisms at XRCC1, XRCC3, XPD, and OGG1 Loci in the Hyderabad Population of India

Narasimha Reddy Parine,Zainularifeen Abduljaleel,Wajahatullah Khan,Akbar Ali Khan Pathan,Varaprasad Bobbarala,Mohammed Alanazi

doi:10.7314/apjcp.2012.13.12.6469

Narasimha Reddy Parine, Zainularifeen Abduljaleel + Show 4 more

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https://doi.org/10.7314/apjcp.2012.13.12.6469

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Abstract

DNA repair is one of the crucial defense mechanism against mutagenic exposure. Inherited SNPs of DNA repair genes may contribute to variation in DNA repair capacity and susceptibility to cancer. Due to the presence of these variants, inter-individual and ethnic differences in DNA repair capacity have been established in various populations. India harbors enormous genetic and cultural diversity. In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population.

Highlights

Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln, XRCC3 Thr241Met, Xeroderma pigmentosum complementation group D (XPD) Lys751Gln, and OGG1 Ser326Cys gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations
The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India
Genetic variation plays a critical role in most diseases, gene-environment interactions may be important in various ways, either by risk due to an individual’s or population genotype, or differential gene risk based on exposure (Gangwar et al, 2002; Iannuzzi et al, 2002)

Summary

Introduction

Genetic variation plays a critical role in most diseases, gene-environment interactions may be important in various ways, either by risk due to an individual’s or population genotype, or differential gene risk based on exposure (Gangwar et al, 2002; Iannuzzi et al, 2002). Any harmful mutations in the DNA repair mechanism genes can lead to genomic instability eventually causing cancer and ageing. Materials and Methods: In the present study we aimed to determine the genotypes and allele frequencies of XRCC1 Arg399Gln (rs25487), XRCC3 Thr241Met (rs861539), XPD Lys751Gln (rs13181), and OGG1 Ser326Cys (rs1052133) gene polymorphisms in 186 healthy individuals residing in the Hyderabad region of India and to compare them with HapMap and other populations. Results and Conclusions: The genotype and allele frequency distribution at the four DNA repair gene loci among Hyderabad population of India revealed a characteristic pattern. Comparison of these gene polymorphisms with other populations revealed a distinctiveness of Hyderabad population from the Deccan region of India. To the best of our knowledge, this is the first report of such DNA repair gene polymorphisms in the Deccan Indian population

Objectives

Methods

Results