Abstract
SummaryHuman skin fibroblasts from neurological and other forms of the disease xeroderma pigmentosum perform repair replication after ultra-violet irradiation at 0 to 25 per cent of normal levels. The reduced repair is correlated with reduced survival in terms of colony formation; normal and xeroderma pigmentosum fibroblasts have exponential survival curves with a D0 of 29 ergs/mm2 and 9 ergs/mm2 respectively. These results demonstrate the importance of repair replication in the survival of irradiated mammalian cells and in the aetiology of xeroderma pigmentosum. Transformation by SV 40 virus does not appear to alter the level of repair replication in xeroderma pigmentosum.
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