Abstract
Esperamicin and calicheamicin are among the most prominent members of enediyne antibiotics. Combining highly unusual molecular structures, potent biological activities, and fascinating modes of action, these DNA-cleaving compounds elicited extensive research activities in chemistry, biology, and medicine. This review weights the oligo (purine/pyrimidine) recognition by esperamicin and calicheamicin. We begin by consideration of the experimental approaches that have been used to provide insights into the recognition process. Next we summarize the recent interpretations of the sources of the specificity to oligo (purine/pyrimidine) sequences.
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