Abstract
Background: This study investigated the effects of an aronia juice-based food supplement on background and total DNA strand breaks in whole blood, and on H2O2-induced DNA strand breaks in isolated peripheral blood lymphocytes. Methods: Ninety-one healthy volunteers were randomly selected to consume either the food supplement (2 × 25 mL drinking ampules, n = 45) or no supplement (n = 46) daily for eight weeks. Results: Background DNA strand breaks decreased significantly after four and eight weeks of supplement consumption, compared to baseline (p < 0.05), but the overall effect was low, and neither group showed a decrease in total DNA strand breaks. Conversely, supplement consumption clearly reduced H2O2-induced DNA strand breaks ex vivo (p < 0.001), with statistically significant reductions after four and eight weeks, compared to the control group (p < 0.05). Conclusions: Thus, although consuming antioxidant supplements might produce only marginal immediate benefits under healthy conditions, potential preventive effects warrant further investigation.
Highlights
Increased formation of reactive oxygen species (ROS) is associated with degenerative diseases like atherosclerosis, Alzheimer’s disease, Parkinson’s disease, and cancer [1]
Several intervention studies reported that consumption of anthocyanin-rich products may protect human DNA integrity and is associated with health benefits [7,8,9,10], where DNA integrity may be assessed by the level of background or total DNA damage
No significant di in background DNA strand breaks were observed between the test and control g strand breaks decreased with no supplement after in background DNA strand breaks were observed between the test and control groups
Summary
Increased formation of reactive oxygen species (ROS) is associated with degenerative diseases like atherosclerosis, Alzheimer’s disease, Parkinson’s disease, and cancer [1]. Several intervention studies reported that consumption of anthocyanin-rich products may protect human DNA integrity and is associated with health benefits [7,8,9,10], where DNA integrity may be assessed by the level of background or total DNA damage. DNA strand breaks (without FPG treatment) in whole blood after the run-in duced background DNA strand breaks after four (p < 0.001) and eight (p < 0.05) weeks. DNA strand breaks decreased with no supplement (control group) a weeks but remained unchanged at the end of the study period. No significant di in background DNA strand breaks were observed between the test and control g strand breaks decreased with no supplement (control group) after Data are expressed as mean tail intensity [%] and SD; BS: blood sampling. 0.41 ± 0.1
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