DNA protection and antioxidant and anti-inflammatory activities of water extract and fermented hydrolysate of abalone (Haliotis discus hannai Ino)

Abstract

Antioxidant and anti-inflammatory activities of water extract and fermented hydrolysate of abalone (Haliotis discus hannai Ino) were examined. Experimental models were used to characterize the antioxidant activities, which were compared with the standard antioxidants α-tocoferol and EDTA (ethylenediamine tetraacetic acid). Antioxidant activities of water extract and fermented hydrolysate were examined at the cellular level and evaluated for anti-inflammatory activities in LPS (lipopolysaccharides)-stimulated murine RAW 264.7 macrophages. Production of the pro-inflammatory mediators nitric oxide (NO) and prostaglandin (PGE2) was significantly (p<0.05) inhibited by treatments with abalone water extract and fermented hydrolysate, compared with controls. Abalone (Haliotis discus hannai Ino) can be considered as a potential source of natural antioxidants and dietary supplements.