Abstract
1. 1. Short-term growth of the plantaris muscle was studied in normal and diabetic rats at 16, 32, 72, and 120 h following surgical ablation of the ipsilateral gastrocnemius muscle. 2. 2. Within 16 h post-surgery both normal and diabetic plantaris muscles had significant increases in wet weight (>30%), total DNA content (>80%), and DNA concentration (>50%). 3. 3. By 120 h the wet weight, total DNA content, and DNA concentration had increased at least 40% 110%, and 60%, respectively. 4. 4. The findings indicated that in chronic hypoinsulinism skeletal muscle retains a normal capacity for DNA proliferation and growth during the acute phase of compensatory hypertrophy.
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