Abstract
DNA polymerase activity was found in chick embryo cells (CEC) that were infected with a tumor virus, strain MC29 (myelocytomatosis) virus. The enzyme activity in homogenates of virus infected cells was greater than in homogenates from noninfected control cells. DNA polymerase activity from noninfected CEC was not able to use the homopolymer duplex, poly dC:poly rG as a template. However, polymerase in cells infected with tumor virus was able to utilize this homopolymer duplex as template, as was the DNA polymerase associated with MC29 virus. The results demonstrated that DNA polymerase activity found in MC29 virus was detectable in the infected-cell homogenate and was distinguished from the cell DNA polymerase by its ability to utilize dC:rG as template.
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