Abstract
The DNA origami method is an extraordinarily powerful and robust method for the assembly of almost arbitrarily shaped nanoscale objects made from DNA. Technological advances such as DNA origami and the availability of a range of computational tools have transformed DNA self-assembly from an art into a genuine engineering discipline. Investigators with diverse backgrounds are now beginning to use the origami method in their field of research. Potential applications range from single molecule bio- and nanophysics over structural biology to synthetic biology and nanomedicine. This article discusses the transition of DNA nanotechnology to molecular scale engineering and describes, citing several examples, the power and utility of DNA origami for scientific research.
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