DNA open complex dynamics in cell mechanobiology

Abstract

Statistically based model of the DNA ensemble evolution allowed the formulation of mechanobiological approach linking the open complex dynamics and different scenarios of gene expression related to normal and cancerous cell behavior. It was shown the correspondence of open complex dynamics to a specific type of criticality in mesodefects ensemble (the structural-scaling transition) in the presence of the mesoscopic potential associated with the epigenetic landscape. The role of open complexes is similar to the mesoscopic defects and provides the cell plasticity or the cell fragility depending on the structural susceptibility of the cytoskeleton structure and the types of collective modes of defects (open complexes). These modes are responsible for the DNA transformation leading to the natural cycle of gene expression and the cell division or spontaneous cell fragmentation with anomalous proliferation as the cancer precursor. The WTMM analysis of the phase thickness fluctuations after the Coherent Phase Microscopy (CPM) of living cells shows the log-normal and power law statistics for normal and cancerous scenarios that are linked to multi- and monofractal dynamics of open complexes.