Abstract
Studies suggest assisted reproductive technologies (ART) cause term placenta methylation differences when compared to spontaneous conceptions. However, 1st trimester placenta, closer to the utilization of fertility treatments has not been well studied. We aimed to determine whether methylation differences affecting gene expression exist in 1st trimester placenta between ART and spontaneous pregnancies and whether ART or infertility are causal. We compared differentially methylated probes (DMPs) in 1st trimester placenta from spontaneous, non in vitro fertilization treatment (NIFT) , and in vitro fertilization (IVF) conceptions to corresponding differences in gene expression in these cohorts.
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