Abstract
BackgroundDimethyl fumarate is an oral treatment for multiple sclerosis, whose mechanism of action is not fully understood.ObjectiveTo investigate the effects of dimethyl fumarate on DNA methylation in the CD4+ T cells of multiple sclerosis patients.MethodsWe performed Illumina EPIC arrays to investigate the DNA methylation profiles of CD4+ T cells derived from multiple sclerosis patients before and after dimethyl fumarate treatment.ResultsTreatment with dimethyl fumarate resulted in 97% of differentially methylated positions showing hypermethylation. Four genes, SNORD1A, SHTN1, MZB1 and TNF had a differentially methylated region located within the transcriptional start site.ConclusionThis study investigates the effect of dimethyl fumarate on DNA methylation in multiple sclerosis patients.
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