Abstract
Two new Schiff base mononuclear CuII and CoIII complexes were synthesized by the condensation of monoethanolamine and o-vanillin precursors. The X-ray crystallography of the complexes were reported. Both complexes had same ligands in their structures with different environment around transition metal ions. Different experimental such as absorption studies, cyclic voltammetry, ethidium bromide displacement studies and viscosity measurement besides of docking method were used to study the binding of the complexes to DNA. Based on these studies, intercalation was proposed to be the main mode of binding for both complexes and CuII complex was a better intercalator in interaction with DNA than CoIII complex. Also, CuII complex triggered double strand break in presence of oxidized agent, H2O2. The MTT and Apoptosis/necrosis analysis were revealed that CuII complex induced apoptosis as compared with anticancer agent, Cisplatin.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
