Abstract
Novel neutral mononuclear copper(II) com- plexes with the antibacterial drug norfloxacin in the presence of nitrogen donor heterocyclic (bipyridines) ligands were synthesized and characterized by elemental analysis, magnetic moment measurement, thermal analysis (TG), IR, LC-MS, and electronic spectra. The complexes were tested against selective gram-positive and -negative organisms for antibacterial activity. DNA binding studies were carried out using viscosity measurement and absorption titration. A DNA cleavage experiment was performed using supercoiled double-stranded DNA plas- mids in order to compare the cleavage efficiency of synthesized copper(II) complexes in the different ligand environments. Superoxide dismutase mimetic behavior was actively sought for clinical and mechanistic purposes under a nonenzymatic system and was found to have good anti- oxidant activity. The in vitro cytotoxic properties of the synthesized complexes were analyzed analogous to the brine shrimp bioassay.
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