Abstract
It is not uncommon to observe autoimmune comorbidities in a significant subset of patients with psychotic disorders, namely schizophrenia (SCZ) and bipolar disorder (BPD). To understand the autoimmune basis, the DNA abyzme activity mediated by serum polyclonal IgG Abs were examined in psychoses patients, quantitatively, by an in-house optimized DNase assay. A similar activity exhibited by IgG Abs from neuropsychiatric-systemic lupus erythematosus (NP-SLE) patients was used as a comparator. Our data revealed that the IgG DNase activity of SCZ was close to that of NP-SLE and it was twofold higher than the healthy controls. Interestingly, the association between DNase activity with PANSS (positive, general and total scores) and MADRS were noted in a subgroup of SCZ and BPD patients, respectively. In our study group, the levels of IL-6 and total IgG in BPD patients were higher than SCZ and healthy controls, indicating a relatively inflammatory nature in BPD, while autoimmune comorbidity was mainly observed in SCZ patients.
Highlights
Growing evidence indicate that neuroinflammation and immune dysfunction play a role in the clinical manifestations of psychotic disorders viz. schizophrenia (SCZ) and bipolar disorder (BPD)[1,2,3]
To further refine the autoimmune features in SCZ and BPD, we investigated the IgG DNA abzyme activity in these patients and compared the activity profile with the IgG from neuropsychiatric-systemic lupus erythematosus (NP-systemic lupus erythematosus (SLE)) patients
To assess the IgG mediated DNase activity quantitatively, our experimental conditions were optimised to determine the antibody concentration and time course required for the scDNA hydrolysis (Fig. 4)
Summary
Growing evidence indicate that neuroinflammation and immune dysfunction play a role in the clinical manifestations of psychotic disorders viz. schizophrenia (SCZ) and bipolar disorder (BPD)[1,2,3].Besides, frequent association of autoimmune comorbidities are reported in psychotic disorders[4]. Growing evidence indicate that neuroinflammation and immune dysfunction play a role in the clinical manifestations of psychotic disorders viz. Epidemiological studies emphasise the involvement of an autoimmune drive in the disease manifestations of SCZ and BPD patients[6]. The psychotic disorders presents several parallels to autoimmune diseases like early-onset, immune dysregulation, the incidence of alternating active-remission disease courses and prevalence of autoantibodies (Aabs)[7]. Genetic association studies along with the impact of environmental factors (infectious stigma, social stress) raise the plausibility that the autoimmune response are either predisposed or proactive in these disorders[8,9]. The occurrence of Aabs in the blood of a significant subset of psychotic patients suggests the involvement of humoral autoimmunity, which might contribute to psychotic manifestations and disease severity[11,12].
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