Abstract
Low drug loading, premature drug leakage, and intratumoral genetic heterogeneity are three main challenges that hinder the successful nanotherapeutics-based oncotherapy, as they provide insufficient therapeutic efficacy, systematic adverse effects, and multidrug resistance, respectively. To address these challenges, we herein develop near-infrared (NIR) laser-sensitive DNA-modified hollow mesoporous silica nanoparticles (HMSNs) with dual cargo loading for chemo-photothermal combined treatment of tumors. Starting from the zeolitic imidazolate framework-8 (ZIF-8) template, a layer of mesoporous silica is coated on ZIF-8 (ZIF-8@MSNs), and subsequently the template is self-degraded under acidic conditions to obtain HMSNs. It is demonstrated that the as-made HMSNs possesses a well-defined morphology, large hollow cavities, and abundant mesoporous structures. After loading of indocyanine green into HMSNs’ core (ICG@HMSNs), the DNA strands, which are composed by sequential cytosine-guanine (CG) base pairs, are t...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
