Abstract
Study of genetic material allows the comprehension the origin of the many biochemical changes that follow diseases, like cancer, promoting the development of early preventive inquiry and more efficient individual treatments. Raman spectroscopy can be an important tool in DNA study, since it allows probe molecular vibrations of genetic material in a fast way. The present work established a systematic way for extract DNA in suitable concentrations and structural integrity allowing studies by Raman spectroscopy or other spectroscopic technique, including bio-analytical sensors for probing genetic alterations.
Highlights
IntroductionThe goal of the frontier research in biomedical field is probe in real time and in a minimally invasive way these changes in a starting stage
Diseases are always associated to biochemical changes
It had been shown to Sensors 2008, 8 be able to differentiate several breast cancer subtypes, skin diseases, degenerative states of tendons, and other pathologic states [3]
Summary
The goal of the frontier research in biomedical field is probe in real time and in a minimally invasive way these changes in a starting stage. This goal could be attached employing spectroscopic techniques as Raman, FTIR, fluorescence, and others to detect these changes. Raman spectroscopy had special significance since it permits analysis without prior sample preparation and in real time [1]. Applications of this technique to diagnosis of diseases (Optical Biopsy) had shown great advances [2]. The objective is finding a methodology providing larger yield, low concentration of expurious specimens, and guarantee of biomolecule structural integrity
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