Abstract
The phosphoramidite 6, a spin labeled analog of thymidine, was synthesized and incorporated into the deoxyoligonucleotide 5′-d(CGCGAATT*CGCG). This substance adepts a duplex structure, as shown by gel electrophoretic mobility. The EPR spectrum of the spin labeled duplex in solution was indicative of subnanosecond probe motion, a result which contrasts with the ca. 5 ns correlation time determined for the corresponding duplex bearing residue 1. Steric inhibition of rotation of the nitroxide-bearing ring of 1 not present in 2 accounts for this difference.
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