Abstract
Heterothallic mating-type switching in Saccharomyces cerevisiae has been shown to be inducible by DNA-damaging agents (Schiestl and Wintersberger, 1983). Different DNA-damaging agents differ greatly in their kinetics of induction during incubation after treatment. Irradiation with X-rays resulted in an increase in the frequency immediately after exposure and no further increase was seen during incubation after treatment. Nitrous acid and 4-nitroquinoline- N-oxide, on the other hand, did not show any increase in frequency immediately after treatment, but require post-treatment incubation to produce an increased frequency of heterothallic mating-type switching. UV irradiation and ethyl methanesulfonate result in induction to certain levels immediately after treatment, but further induction was seen during post-treatment incubation. The results may indicate that certain kinds of DNA damage require repair or replication to be converted into recombinogenic lesions.
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