Abstract
Hypohalites (OCl −, OBr −) are formed at inflammation sites as antimicrobial agents. OCl − is also used for the disinfection of water supplies and the association of drinking chlorinated water with cancer risk is pointed out. In this study, OCl − itself induced 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) formation, while OBr − damaged DNA only when glutathione (GSH) was added. OCl − caused oxidative DNA damage more efficiently than OBr −/GSH. In experiment with 32P-labeled DNA fragments, OCl − strongly caused piperidine-labile sites at guanine residues than piperidine-inert 8-oxodG, whereas OBr −/GSH caused no piperidine-labile sites. Endogenous OCl − may play a role in genotoxicity close to the site of inflammation.
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