Abstract
DNA Damage and Lung Cancer Risk in Tobacco Smokers
Highlights
Lung cancer is currently the leading cause of cancer death in the world [1]
We reviewed the four epidemiological studies that have examined the dose-response relationship of polycyclic aromatic hydrocarbons (PAH)-related DNA adducts with lung cancer using 32P-postlabeling by pooled- or meta-analytic approach
Pooled and metaanalysis of longitudinal prospective studies, were the measurement of adducts was performed in peripheral blood that was collected years before cancer onset, confirmed that the production of PAH-related DNA adducts was associated with lung cancer in smokers with an overall estimate of 34% increase as compared to referents (95% Confidence Interval 1.10-1.64)
Summary
Meta-analyses of case-control and cohort studies with a final data set containing data for 1,028 lung, oral and bladder cancer patients and 1,084 controls showed higher frequency of DNA damage in smokers in respect to referents. When only lung cancer was considered, smokers were having 79% (95% Confidence Interval 0.33-1.25) higher levels of PAH-related adducts as compared to controls. Pooled and metaanalysis of longitudinal prospective studies, were the measurement of adducts was performed in peripheral blood that was collected years before cancer onset, confirmed that the production of PAH-related DNA adducts was associated with lung cancer in smokers with an overall estimate of 34% increase as compared to referents (95% Confidence Interval 1.10-1.64)
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