Abstract
DNA Damage and Lung Cancer Risk in Tobacco Smokers
Highlights
Lung cancer is currently the leading cause of cancer death in the world [1]
Pooled and meta-analysis indicate that smokers with greater levels of DNA damage have increased risk of lung cancer
The overall excess of adducts in smokers with lung cancer in respect to controls supports the value of adducts as a predictive biomarker, that might be used to select high risk subjects for cancer screening programs
Summary
Meta-analyses of case-control and cohort studies with a final data set containing data for 1,028 lung, oral and bladder cancer patients and 1,084 controls showed higher frequency of DNA damage in smokers in respect to referents. When only lung cancer was considered, smokers were having 79% (95% Confidence Interval 0.33–1.25) higher levels of PAH-related adducts as compared to controls. Pooled and meta-analysis of longitudinal prospective studies, were the measurement of adducts was performed in peripheral blood that was collected years before cancer onset, confirmed that the production of PAH-related DNA adducts was associated with lung cancer in smokers with an overall estimate of 34% increase as compared to referents (95% Confidence Interval 1.10–1.64)
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