Abstract
Infection of the human KB cell line with Frog Virus 3 brought about a partial degradation of radioactively labeled cell DNA as determined by alkaline sucrose sedimentation analysis. Further characterisation of this phenomenon revealed that degradation only occured when a sufficiently large amount of radioactive precursors was previously incorporated into the cell DNA. Therefore DNA damage appeared to be the result of a combined effect of incorporated radioisotopes and viral infection. It is suggested that the degradation of the radioactively labeled cell DNA could be a consequence of the inhibition of cell protein synthesis by frog Virus 3 since treatment of the cells with cycloheximide also led to DNA degradation.
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