Abstract
AbstractMicrocystin‐LR (MC‐LR) and nodularin (NOD), two potent cyanotoxins with strong hepatotoxic, genotoxic and carcinogenic potential have been associated with the induction of deoxyribonucleic acid (DNA) damage in vitro and in vivo. Electrochemical studies were performed to understand the DNA interaction mechanisms with MC‐LR and NOD using a dsDNA‐electrochemical biosensor and incubated solutions. The decrease of the dsDNA oxidation peaks with increasing incubation time due to aggregation of DNA strands and the liberation of adenine free residues, causing the occurrence of DNA abasic sites, was observed, which may introduce mutations in the dsDNA during the replication process.
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