Abstract
The DNA content of individual nuclei in biopsies of normal cervical epithelium, dysplasia, and carcinoma in situ was estimated by microspectrophotometric measurements of Feulgen-stained sections. The normal epithelium had a diploid modal value and a diploid-tetraploid range whereas in all cases of dysplasia and carcinoma in situ there were significant numbers of cells with a DNA content significantly above this range and with an abnormal mode. The degree of deviation of the DNA values from the normal distribution was least in the mild dysplasias but became more pronounced in the higher grade lesions. These observations are consistent with the concept that the lesions studied are related as part of a continuum.
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