Abstract
The application of DNA-based hybrid catalysts for enantioselective synthesis has recently emerged. These catalysts, self-assembled from DNA and a metal complex with a specific ligand through supramolecular or covalent anchoring strategies, have demonstrated high enantioselectivity in a variety of carbon-carbon or carbon-heteroatom bond-forming reactions and have expanded their role in asymmetric catalysis. In this review, we summarize the advent and significant progress of DNA-based asymmetric catalysis and discuss remaining challenges in using DNA as a chiral scaffold. We hope that this review will inspire many of today’s active scientists in asymmetric catalysis.
Highlights
Nature selects only one enantiomer of a molecule to function appositely in a living cell and produces chiral molecules using enzymes that catalyze asymmetric reactions with exquisite selectivity beyond conventional synthetic methods
Helical chirality has received attention as a simple and highly organized chiral structure for asymmetric synthesis and significant advances have been reported, earlier workers relied on the use of synthetic helical polymers [10,11,12,13,14,15,16,17]
DNA is a promising candidate as a source of chirality in asymmetric catalysis in many respects
Summary
Nature selects only one enantiomer of a molecule to function appositely in a living cell and produces chiral molecules using enzymes that catalyze asymmetric reactions with exquisite selectivity beyond conventional synthetic methods. Taking inspiration from this prowess, many researchers have investigated stereoselective hybrid catalysts that combine the catalytic power of a metal complex with the exquisite chirality of a biomolecule as alternative tools for the synthesis of enantiomerically pure. Helical chirality has received attention as a simple and highly organized chiral structure for asymmetric synthesis and significant advances have been reported, earlier workers relied on the use of synthetic helical polymers [10,11,12,13,14,15,16,17]. We will discuss the advent and the significant progress of DNA-based asymmetric catalysis and highlight the remaining challenges in using DNA as a chiral scaffold
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
