Abstract
Abstract A brief review of the literature on syn dihydrodiol epoxide DNA adducts is presented. NMR studies indicate that bay region substituents influence the conformation of the partially saturated ring in such adducts. However, only substitutions that lead to distortion from planarity are associated with reactivity towards deoxyadenosine residues in DNA and with greater tumorigenicity. This is similar to the situation that obtains for anti dihydrodiol epoxides.
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