Abstract
In dystrophic mdx mouse and dog models of Duchenne muscular dystrophy (DMD) repeated intrinsic muscle necrosis also damages the neuromuscular junctions (NMJs) with progressively altered NMJ morphology. We propose that these altered NMJs result in premature changes in dystrophic nerves and this was tested by immunoblotting. These analyses were built upon our observations related to normal ageing and sarcopenia, where time course studies show denervation of NMJs and myofibres along with neurodegeneration of peripheral nerves by 18 to 22 months(m), and also changes in normal old spinal cords.
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