Düşük Yoğunluklu Kırmızı ve Kızılötesi Lazer Işın Tedavisinin Tavşanlarda Birbirine Geçmeyen Tam Kalınlıklı Serbest Deri Otogrefti Üzerine Etkisi: Bir Hayvan Modeli

Abstract

Summary The effect of laser on wound healing has been approved but the role of Low Red (LR) and Infrared Low Level Laser (ILLL) on unmeshed full-thickness free skin autograft (UFFSA) is not clear yet. The aim of the present experimental study is to determine the effectiveness of LR and ILLL in UFFSA in rabbits. The study was conducted on 15 New-Zealand white rabbits were divided into three groups, Control (C), Low Red (LR), Low Infrared (LIR). A 5×5 cm UFFSA was obtained then rotated 90 degrees and repositioned on its own bed and sutured. The rabbits in LR and LIR received LR and ILLL for 6 days post-operatively. On days 3, 5, 7, 14, and 30 skin biopsies were obtained. Graft size was measured. There were significant differences in epitheliazition, polymorphonuclears, fibroblast, and collagen among groups on days 3 and 5 and new vessels on day 3. LR and LIR had similar role in new vessels till day 5 and collagen synthesis on day 3 for group C. There was no significant difference in epithelialization in groups on days 7, 14, and 30. LIR showed significant differences of length, area, peripheral, and diameter during study and of width on day 7. We concluded LIR played the more effective role on early phase (on day 5) of healing and more acceptable appearance to LR and C groups on quantitative measures.